The ES 300h is available in a single Base trim level. A 2.5-liter four-cylinder hybrid gas and electric motor produces 200 horsepower. Front-wheel drive and a continuously variable automatic transmission (CVT) are standard. Standard features include: cruise control, a sunroof, keyless entry, keyless ignition, 17-inch alloy wheels, eight-way power seats with power lumbar support, LED running lights, heated mirrors, automatic headlights, dual-zone climate control, an auto-dimming rearview mirror, Bluetooth, an eight-speaker sound system, a six-disc CD changer, an iPod interface, an auxiliary audio jack, premium upholstery, tilt and telescoping steering, and Lexus Safety Connect emergency service.

Options are plentiful. An Audio Package adds the Lexus Remote Touch interface, Bluetooth streaming audio, a rearview camera, an HD radio with iTunes tagging, and an enhanced phone function. The Navigation Package includes a navigation system, voice controls, and smartphone apps. Several standalone options include a 15-speaker audio upgrade with surround-sound, and a DVD system.

Lexus also offers the Premium Package, Luxury Package, and Ultra Luxury Package. These include various combinations of options like power-adjustable steering, driver memory, wood trim, xenon headlamps, parking sensors, heated and ventilated seats, leather upholstery, a rear power sunshade, a ten-way power driver's seat, a heated steering wheel, automatic wipers, parking sensors, passenger seat memory, and ambient lighting. Individual options from these packages include lane departure systems, automatic high beams, adaptive cruise control, a blind-spot warning system, a pre-collision system, and rear cross-traffic alert.