Yes, there is a difference between enamel car paint and acrylic car paint. Enamel paints are traditionally oil based, while acrylic car paint is always water based. Additionally, acrylic car paint normally results in a matte finish that can then be covered in a clear coat, while enamels naturally dry to a glossy finish. There is also a car paint called acrylic enamel paint, which refers to a water based enamel paint. This type of paint is generally considered inferior to acrylic urethane paint, as the urethane-based paint features improved UV protection, which resists fading in the sunlight.